Genetic Methylation Testing & Treatment

What Is Methylation and Why Is It Important?

Methylation is a vital biochemical process that happens in every cell of your body. It plays a key role in:

  • Detoxification

  • Hormone metabolism

  • Energy production

  • Immune function

  • Brain chemistry and mood

  • Inflammation regulation

  • Cardiovascular health

When methylation works well, your body runs smoothly. But if there are genetic variations—especially in methylation-related genes—it can lead to imbalances and chronic symptoms.

What Are SNPs (Single Nucleotide Polymorphisms)?

SNPs are small genetic variations that can affect how efficiently your body performs certain tasks. In the case of methylation, SNPs may slow down or impair your ability to process B vitamins, clear toxins, manage stress, and more.

Some of the most commonly tested SNPs include:

  • MTHFR – affects folate metabolism and homocysteine levels

  • COMT – impacts the breakdown of stress hormones and estrogen

  • CBS – affects sulfur metabolism and detoxification

  • MAO-A – plays a role in serotonin and dopamine regulation

  • MTR & MTRR – influence B12 utilization and methylation cycles

Symptoms and Health Issues Linked to Methylation Imbalances

Impaired methylation due to SNPs can lead to a wide variety of symptoms and chronic health challenges, including:

  • Fatigue or low energy

  • Brain fog or memory issues

  • Anxiety, depression, or mood swings

  • Hormonal imbalances (PMS, estrogen dominance, low testosterone)

  • Poor sleep or insomnia

  • Sensitivity to chemicals, medications, or alcohol

  • Headaches or migraines

  • Inflammation or joint pain

  • High homocysteine or cardiovascular risk

  • Fertility issues or pregnancy complications

  • Autoimmune conditions

Even if these issues seem unrelated, methylation dysfunction can be a common thread.

Common Ways to Support SNPs

If you have methylation-related SNPs, there are many effective strategies to support your body. Functional medicine focuses on personalized solutions, but here are some common ways we help support methylation:

1. Use Activated B Vitamins

  • Methylfolate (5-MTHF) and methylcobalamin (B12) are essential for those with MTHFR or MTR mutations. These forms are already “methylated,” so they’re easier for the body to use.

  • P-5-P (active B6) and riboflavin (B2) also support critical enzyme activity.

2. Optimize Nutrition

  • Eat a diet rich in leafy greens, colorful vegetables, clean proteins, and healthy fats.

  • Limit processed foods, alcohol, and synthetic additives that can stress detox pathways.

  • Include foods high in natural folate (spinach, lentils, avocados) and B12 (grass-fed meat, eggs, wild fish).

3. Reduce Toxin Exposure

  • Use non-toxic household and personal care products.

  • Filter your water and air when possible.

  • Avoid unnecessary medications that may strain your detox systems.

4. Manage Stress

  • High stress increases demand on methylation and detox pathways (especially if COMT or MAO-A variants are present).

  • Incorporate meditation, breathwork, yoga, or other calming practices regularly.

5. Support Detox Pathways

  • Use targeted nutrients like NAC, glutathione, or milk thistle to help the liver clear toxins.

  • Regular sweating through sauna or exercise can also assist in detox.

  • Ensure regular, healthy bowel movements to prevent toxin buildup.

6. Address Gut Health

  • A healthy microbiome supports proper nutrient absorption and detox.

  • Probiotics, digestive enzymes, and anti-inflammatory nutrition can make a big difference.

7. Monitor and Adjust Supplements

  • Over-supplementing (especially with methylated B vitamins) can lead to symptoms like anxiety or insomnia.

  • Personalized dosing is key, based on labs and how you feel.

Our Functional Medicine Approach

We offer comprehensive genetic methylation testing along with personalized treatment plans that combine:

  • Detailed genetic and nutrient testing

  • Customized supplement protocols

  • Dietary and lifestyle support

  • Ongoing guidance and monitoring

Our goal is to help you optimize your health by working with your genes — not against them.

Take the Next Step Toward Personalized Wellness

If you’re struggling with chronic symptoms or simply want to optimize your health, methylation testing may provide the answers you’ve been looking for.

Schedule a consultation today and discover how your genetics can help guide your path to lasting wellness.